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Miscarriage

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Miscarriages are the most common complication of pregnancy. The medical term "spontaneous abortion" is used in reference to miscarriages because the medical term "abortion" refers to any terminated pregnancy, deliberately induced or spontaneous, although in common parlance it refers specifically to active termination of pregnancy.

Very early miscarriages - those which occur before the sixth week LMP (since the woman's Last Menstrual Period) are medically termed early pregnancy loss or chemical pregnancy. Miscarriages that occur after the sixth week LMP are medically termed clinical spontaneous abortion.

In medical contexts, the word "abortion" refers to any process by which a pregnancy ends with the death and removal or expulsion of the fetus, regardless of whether it's spontaneous or intentionally induced. Many women who have had miscarriages, however, object to the term "abortion" in connection with their experience, as it is generally associated with induced abortions. In recent years there has been discussion in the medical community about avoiding the use of this term in favor of the less ambiguous term "miscarriage."

Labour resulting in live birth before the 37th week of pregnancy is termed "premature birth," even if the infant dies shortly afterward. Although long-term survival has never been reported for infants born from pregnancy shorter than 21 weeks, infants born as early as the 16th week of pregnancy may cry and live a few minutes or hours.

A fetus that dies while in the uterus after about the 20th week of pregnancy is termed a "stillbirth". Premature births or stillbirths are not generally considered miscarriages, though usage of the terms and causes of these events may overlap.

Causes

Miscarriages can occur for many reasons, not all of which can be identified.

First trimester

Most miscarriages (more than three-quarters) occur during the first trimester.

Chromosomal abnormalities are found in more than half of embryos miscarried in the first 13 weeks. A pregnancy with a genetic problem has a 95% chance of ending in miscarriage. Most chromosomal problems happen by chance, have nothing to do with the parents, and are unlikely to recur. Genetic problems are more likely to occur with older parents; this may account for the higher miscarriage rates observed in older women.

Another cause of early miscarriage may be progesterone deficiency. Women diagnosed with low progesterone levels in the second half of their menstrual cycle (luteal phase) may be prescribed progesterone supplements, to be taken for the first trimester of pregnancy.

Second trimester

Up to 15% of pregnancy losses in the second trimester may be due to uterine malformation, growths in the uterus (fibroids), or cervical problems. These conditions may also contribute to premature birth.

One study found that 19% of second trimester losses were caused by problems with the umbilical cord. Problems with the placenta may also account for a significant number of later-term miscarriages.

General risk factors

Pregnancies involving more than one fetus are at increased risk of miscarriage.

Uncontrolled diabetes greatly increases the risk of miscarriage. Women with controlled diabetes are not at higher risk of miscarriage. Because diabetes may develop during pregnancy (gestational diabetes), an important part of prenatal care is to monitor for signs of the disease. High blood pressure and certain illnesses (such as rubella and chlamydia) increase the risk of miscarriage.

Tobacco (cigarette) smokers have an increased risk of miscarriage. An increase in miscarriage is also associated with the father being a cigarette smoker. The husband study observed a 4% increased risk for husbands who smoke less than 20 cigarettes/day, and an 81% increased risk for husbands who smoke 20 or more cigarettes/day.

Severe cases of hypothyroidism increase the risk of miscarriage. The effect of milder cases of hypothyroidism on miscarriage rates has not been established. Certain immune conditions such as autoimmune diseases greatly increase the risk of miscarriage.

Cocaine use increases miscarriage rates.

Physical trauma, exposure to certain chemicals, obesity, high caffeine intake (> 300 mg/day), high levels of alcohol consumption, and use of NSAIDs have also been linked to increased risk of miscarriage.

 

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